Stereoselectivity in the double reductive alkylation of pyrroles:: synthesis of cis-3,4-disubstituted pyrrolidines

被引:10
作者
Donohoe, TJ
Harji, RR
Cousins, RPC
机构
[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
关键词
D O I
10.1039/a809193e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The preparation and Birch reduction of a 1,3,4-tri-substituted pyrrole is described: the heterocycle is loaded with electron-withdrawing groups and undergoes a double reductive alkylation reaction to yield cis-3,4-disubstituted pyrrolidines.
引用
收藏
页码:141 / 142
页数:2
相关论文
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VANLEUSEN AM, 1972, TETRAHEDRON LETT, P5337