Photodynamic Inactivation of Mammalian Viruses and Bacteriophages

被引：182

作者：

Costa, Liliana ^{[1
,2
]}

Faustino, Maria Amparo F. ^{[3
,4
]}

Neves, Maria Graca P. M. S. ^{[3
,4
]}

Cunha, Angela ^{[1
,2
]}

Almeida, Adelaide ^{[1
,2
]}

机构：

[1] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal

[2] Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal

[3] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[4] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

来源：

VIRUSES-BASEL | 2012年 / 4卷 / 07期

关键词：

bacteriophages; mammalian viruses; photodynamic therapy; photosensitizer; viral photoinactivation process; HUMAN-IMMUNODEFICIENCY-VIRUS; VESICULAR STOMATITIS-VIRUS; BLUE PLUS LIGHT; METHYLENE-BLUE; SINGLET OXYGEN; PORPHYRIN DERIVATIVES; 5-AMINOLEVULINIC ACID; CATIONIC PORPHYRINS; ENVELOPED VIRUSES; MESO-TETRAPHENYLPORPHYRINS;

D O I：

10.3390/v4071034

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i) summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii) discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.

引用

页码：1034 / 1074

页数：41

共 171 条

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Potential involvement of both type I and type II mechanisms in M13 virus inactivation by methylene blue photosensitization [J].