A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

被引：50

作者：

Kohler, JA ^{[1
]}

Imeson, J

Ellershaw, C

Lie, SO

机构：

[1] Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

[2] Univ Leicester, Dept Epidemiol & Publ Hlth, United Kingdom Childrens Canc Study Grp, Leicester LE1 6TP, Leics, England

[3] Natl Hosp Norway, Dept Pediat, N-0027 Oslo, Norway

来源：

BRITISH JOURNAL OF CANCER | 2000年 / 83卷 / 09期

关键词：

13-Cis retinoic acid; neuroblastoma;

D O I：

10.1054/bjoc.2000.1425

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid. (C) 2000 Cancer Research Campaign.

引用

页码：1124 / 1127

页数：4

共 13 条

[11]

REYNOLDS CP, 1991, PROG CLIN BIOL RES, V366, P203

[12] DECREASED EXPRESSION OF N-MYC PRECEDES RETINOIC ACID-INDUCED MORPHOLOGICAL-DIFFERENTIATION OF HUMAN NEURO-BLASTOMA [J].

THIELE, CJ ;

REYNOLDS, CP ;

ISRAEL, MA .

NATURE, 1985, 313 (6001) :404-406

[13] PHASE-I TRIAL OF 13-CIS-RETINOIC ACID IN CHILDREN WITH NEUROBLASTOMA FOLLOWING BONE-MARROW TRANSPLANTATION [J].

VILLABLANCA, JG ;

KHAN, AA ;

AVRAMIS, VI ;

SEEGER, RC ;

MATTHAY, KK ;

RAMSAY, NKC ;

REYNOLDS, CP .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (04) :894-901

← 1 2 →