Intracellular Ca2+ signaling and human disease:: The hunt begins with Huntington's

被引：10

作者：

Varshney, A ^{[1
]}

Ehrlich, BE ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol & Cellular & Mol Physiol, New Haven, CT 06520 USA

来源：

NEURON | 2003年 / 39卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(03)00425-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Huntingtin, a protein altered by polyglutamine expansion in Huntington's disease (Htt(exp)), forms a signaling complex with the InsP(3)R, an intracellular calcium channel, and Htt-associated protein 1A (HAP1A). The addition of Htt(exp) increases the InsP(3)R sensitivity to InsP(3), which subsequently makes neurons hyperresponsive to stimulation and presumably more prone to neurodegenerative processes.

引用

页码：195 / 197

页数：3

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