Kinetic nonoptimality and vibrational stability of proteins

被引：16

作者：

Cieplak, M ^{[1
]}

Hoang, TX ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Phys, Warsaw, Poland

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2001年 / 44卷 / 01期

关键词：

protein folding; Go model; molecular dynamics; protein stability;

D O I：

10.1002/prot.1067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scaling of folding times in Go models of proteins and of decoy structures with the Lennard-Jones potentials in the native contacts reveal power law trends when studied under optimal folding conditions. The power law exponent depends on the type of native geometry. Its value indicates lack of kinetic optimality in the model proteins. In proteins, mechanical and thermodynamic stabilities are correlated. Proteins 2001;44:20-25. (C) 2001 Wiley-Liss, Inc.

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页码：20 / 25

页数：6

相关论文

共 43 条

[1] NON-INTERACTING LOCAL-STRUCTURE MODEL OF FOLDING AND UNFOLDING TRANSITION IN GLOBULAR-PROTEINS .2. APPLICATION TO TWO-DIMENSIONAL LATTICE PROTEINS [J].

ABE, H ;

GO, N .

BIOPOLYMERS, 1981, 20 (05) :1013-1031

[2] Matching theory and experiment in protein folding [J].

Alm, E ;

Baker, D .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (02) :189-196

[3] Cannabinoids control spasticity and tremor in a multiple sclerosis model [J].

Baker, D ;

Pryce, G ;

Croxford, JL ;

Brown, P ;

Pertwee, RG ;

Huffman, JW ;

Layward, L .

NATURE, 2000, 404 (6773) :84-87

[4] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[5] Modeling evolutionary landscapes: Mutational stability, topology, and superfunnels in sequence space [J].

Bornberg-Bauer, E ;

Chan, HS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10689-10694

[6] FUNNELS, PATHWAYS, AND THE ENERGY LANDSCAPE OF PROTEIN-FOLDING - A SYNTHESIS [J].

BRYNGELSON, JD ;

ONUCHIC, JN ;

SOCCI, ND ;

WOLYNES, PG .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1995, 21 (03) :167-195

[7] Entropic barriers, frustration, and order: Basic ingredients in protein folding [J].

Camacho, CJ .

PHYSICAL REVIEW LETTERS, 1996, 77 (11) :2324-2327

[8] Protein folding - Matching speed and locality [J].

Chan, HS .

NATURE, 1998, 392 (6678) :761-763

[9] Master equation approach to protein folding and kinetic traps [J].

Cieplak, M ;

Henkel, M ;

Karbowski, J ;

Banavar, JR .

PHYSICAL REVIEW LETTERS, 1998, 80 (16) :3654-3657

[10] Scaling of folding properties in simple models of proteins [J].

Cieplak, M ;

Hoang, TX ;

Li, MS .

PHYSICAL REVIEW LETTERS, 1999, 83 (08) :1684-1687

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