Protein folding - Matching speed and locality

被引:57
作者
Chan, HS [1 ]
机构
[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA
关键词
D O I
10.1038/33808
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The study of protein folding is both a theoretical and an experimental discipline. But whereas experimentalists generally study specific proteins, theoreticians often use models that apply only to generic proteins. Can the two be reconciled? One study goes some way towards this through a statistical analysis of measured folding rates and theoretical determinants. The authors conclude that, for one group of proteins, the speed of folding depends on the number of local versus non-local contacts between amino-acid residues in the protein.
引用
收藏
页码:761 / 763
页数:3
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