Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus

被引：21

作者：

Adachi, K

Kanoh, K

Wisespongp, P

Nishijima, M

Shizuri, Y

机构：

[1] Marine Biotechnol Inst Co Ltd, Kamaishi 0260001, Japan

[2] NCIMB Japan Co Ltd, Shimizu, Shizuoka 4240065, Japan

[3] Kasetsart Univ Chatuchak, Fac Fisheries, Dept Marine Sci, Bangkok 10900, Thailand

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 02期

关键词：

clonostachysin; anti-dinoflagellate; cyclic peptides; marine; fungus;

D O I：

10.1038/ja.2005.17

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 muM, but had no effect on other microalgae and bacteria even at 100 muM.

引用

页码：145 / 150

页数：6

共 11 条

[1]

ADACHI K, 1998, Patent No. 11335210

[2]

Biabani MAF, 1998, J ANTIBIOT, V51, P333

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