Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors

被引：200

作者：

Takahashi, T ^{[1
]}

Nakamura, F ^{[1
]}

Jin, Z ^{[1
]}

Kalb, RG ^{[1
]}

Strittmatter, SM ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06520 USA

来源：

NATURE NEUROSCIENCE | 1998年 / 1卷 / 06期

关键词：

D O I：

10.1038/2203

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor; that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons. By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness. SemA and SemE block SemD binding to NP-1 and abolish SemD repulsion in axons expressing NP-1. SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2.

引用

页码：487 / 493

页数：7

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