Synthesis of dimeric Lewis X antigenic determinant with azido-type spacer arm by a sequence of regioselective glycosylation steps

被引：18

作者：

Figueroa-Perez, S ^{[1
]}

Verez-Bencomo, V ^{[1
]}

机构：

[1] Univ La Habana, Fac Quim, Lab Synthet Antigens, Cuidad Habana 10400, Cuba

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(98)02104-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new regioselective glycosylation strategy was used to develop a highly efficient synthesis of the dimeric Lewis X determinant linked to an azido type spacer arm. Regioselective galactosylation of 3,4 glucosamine diols 2 and 3 with galactose donor 4, followed by fucosylation provided two trisaccharide building blocks 9 and 10. The final condensation involved a 3b-regioselective glycosylation of the 2b,3b trisaccharide diol 11 in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9143 / 9146

页数：4

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