Chemoenzymatic synthesis of α-halogeno-3-octanol and 4- or 5-nonanols.: Application to the preparation of chiral epoxides

被引：17

作者：

Besse, P ^{[1
]}

Sokoltchik, T ^{[1
]}

Veschambre, H ^{[1
]}

机构：

[1] Univ Blaise Pascal, Lab Synth Electrosynth & Etud Syst Interet Biol, CNRS, UMR 6504, F-63177 Aubiere, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(98)00470-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A study of the microbiological reduction of different alpha-halogenoketones (4-chloro-3-octanone, 4-chloro-5-nonanone, 5-bromo-4-nonanone and 5-chloro-4-nonanone) with several strains of microorganism showed great difficulty in reducing ketone functions located in the middle of carbon chains. However, by choosing the appropriate microorganism, several enantiomerically pure diastereoisomers of the corresponding halohydrins have been obtained and were transformed into chiral epoxides. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4441 / 4457

页数：17

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