Association studies for asthma and atopic diseases: a comprehensive review of the literature

被引:133
作者
Hoffjan, S
Nicolae, D
Ober, C [1 ]
机构
[1] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Stat, Chicago, IL 60637 USA
关键词
D O I
10.1186/1465-9921-4-14
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.
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页数:12
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共 280 条
[1]   Novel polymorphism in the coding region of the IL-13 receptor alpha′ gene:: Association study with atopic asthma in the Japanese population [J].
Ahmed, S ;
Ihara, K ;
Sasaki, Y ;
Nakao, F ;
Nishima, S ;
Fujino, T ;
Hara, T .
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, 2000, 17 (01) :18-22
[2]  
Albuquerque RV, 1998, CLIN EXP ALLERGY, V28, P578
[3]   Polymorphism in the STAT6 gene encodes risk for nut allergy [J].
Amoli, MM ;
Hand, S ;
Hajeer, AH ;
Jones, KP ;
Rolf, S ;
Sting, C ;
Davies, BH ;
Ollier, WER .
GENES AND IMMUNITY, 2002, 3 (04) :220-224
[4]   Analysis of the Ser786Pro interleukin-4 receptor α allelic variant in allergic and nonallergic asthma and its functional consequences [J].
Andrews, RP ;
Burrell, L ;
Rosa-Rosa, L ;
Cunningham, CM ;
Brzezinski, JL ;
Bernstein, JA ;
Hershey, GKK .
CLINICAL IMMUNOLOGY, 2001, 100 (03) :298-304
[5]   HUMAN IMMUNE RESPONSIVENESS TO LOLIUM-PERENNE POLLEN ALLERGEN LOL-P-III (RYE-III) IS ASSOCIATED WITH HLA-DR3 AND DR5 [J].
ANSARI, AA ;
FREIDHOFF, LR ;
MEYERS, DA ;
BIAS, WB ;
MARSH, DG .
HUMAN IMMUNOLOGY, 1989, 25 (01) :59-71
[6]   Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma [J].
Arima, K ;
Umeshita-Suyama, R ;
Sakata, Y ;
Akaiwa, M ;
Mao, XQ ;
Enomoto, T ;
Dake, Y ;
Shimazu, S ;
Yamashita, T ;
Sugawara, N ;
Brodeur, S ;
Geha, R ;
Puri, RK ;
Sayegh, MH ;
Adra, CN ;
Hamasaki, N ;
Hopkin, JM ;
Shirakawa, T ;
Izuhara, K .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (06) :980-987
[7]   Atopic dermatitis is associated with a low-producer transforming growth factor β1 cytokine genotype [J].
Arkwright, PD ;
Chase, JM ;
Babbage, S ;
Pravica, V ;
David, TJ ;
Hutchinson, IV .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :281-+
[8]   Evidence of a strong, positive association between atopy and the HLA class II alleles DR4 and DR7 [J].
Aron, Y ;
DesmazesDufeu, N ;
Matran, R ;
Polla, BS ;
Dusser, D ;
Lockhart, A ;
Swierczewski, E .
CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (07) :821-828
[9]   A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E [J].
Baldini, M ;
Lohman, IC ;
Halonen, M ;
Erickson, RP ;
Holt, PG ;
Martinez, FD .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (05) :976-983
[10]   CD14: an example of gene by environment interaction in allergic disease [J].
Baldini, M ;
Vercelli, D ;
Martinez, FD .
ALLERGY, 2002, 57 (03) :188-192