Association studies for asthma and atopic diseases: a comprehensive review of the literature

被引：133

作者：

Hoffjan, S

Nicolae, D

Ober, C ^{[1
]}

机构：

[1] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Stat, Chicago, IL 60637 USA

来源：

RESPIRATORY RESEARCH | 2003年 / 4卷 / 14期

关键词：

D O I：

10.1186/1465-9921-4-14

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

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