Does Inflammation in an Autoimmune Disease Differ from Inflammation in Neurodegenerative Diseases? Possible Implications for Therapy

被引：20

作者：

Schwartz, Michal ^{[1
]}

Butovsky, Oleg ^{[1
]}

Kipnis, Jonathan ^{[2
,3
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[2] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE 68198 USA

[3] Univ Nebraska Med Ctr, Dept Ophthalmol & Visual Sci, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE 68198 USA

来源：

JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2006年 / 1卷 / 01期

关键词：

neurodegeneration; neuroprotection; protective autoimmunity; activated microglia;

D O I：

10.1007/s11481-005-9010-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Accumulating evidence suggests that neurodegenerative diseases of the central nervous system (CNS) are associated with a local inflammatory response. CNS autoimmune diseases are also associated with inflammation. Does this mean that all neurodegenerative diseases are autoimmune in nature? Does it imply that autoimmune and neurodegenerative diseases are both eligible for the same therapy? What distinguishes between the two types of disease? Do they differ both in etiology and in pathology, or do they have different etiologies but similar pathology and progression? In this minireview we offer a new view of the inflammatory differences between neurodegenerative and autoimmune diseases in the CNS and discuss the implications for therapy.

引用

页码：4 / 10

页数：7

共 83 条

[1]

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1 [J].