Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles

被引：17

作者：

Hovland, Anders ^{[1
,2
]}

Marcovina, Santica ^{[3
]}

Hardersen, Randolf ^{[4
]}

Enebakk, Terje ^{[4
]}

Mollnes, Tom Eirik ^{[5
,6
]}

Lappegard, Knut Tore ^{[1
,2
]}

机构：

[1] Nordland Hosp, Div Internal Med, Coronary Care Unit, Bodo, Norway

[2] Univ Tromso, Inst Clin Med, N-9001 Tromso, Norway

[3] Univ Washington, NW Lipid Metab & Diabet Res Labs, Seattle, WA 98195 USA

[4] Nordland Hosp, Div Internal Med, Dialysis Unit, Bodo, Norway

[5] Nordland Hosp, Somat Res Lab, Bodo, Norway

[6] Univ Tromso, Inst Med Biol, N-9001 Tromso, Norway

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2012年 / 46卷 / 01期

关键词：

Familial hypercholesterolemia; LDL apheresis; LDL cholesterol; Lipoprotein(a); Atherosclerosis; CORONARY-HEART-DISEASE; SERUM LIPOPROTEIN(A); RISK-FACTOR; ISOFORMS; REMOVAL; NUMBER; LP(A);

D O I：

10.1016/j.transci.2011.11.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: High levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH). Results: Average Lp(a) concentration was reduced by 70%, 74% and 75% (all p < 0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32 K 4 domains were observed after apheresis. Conclusion: Three different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：73 / 76

页数：4

共 31 条

[1] 26 Years of LDL-Apheresis: A review of experience [J].

Borberg, H. .

TRANSFUSION AND APHERESIS SCIENCE, 2009, 41 (01) :49-59

[2] Comparison of different Lp (a) elimination techniques: A retrospective evaluation [J].

Borberg, Helmut .

TRANSFUSION AND APHERESIS SCIENCE, 2009, 41 (01) :61-65

[3] Elevated Lp(a) with a small apo(a) isoform in children: risk factor for the development of premature coronary artery disease [J].

Dirisamer, Albert ;

Widhalm, Harald ;

Aldover-Macasaet, Elsie ;

Molzer, Sylvia ;

Widhalm, Kurt .

ACTA PAEDIATRICA, 2008, 97 (12) :1653-1657

[4] Apolipoprotein(a) Isoforms and the Risk of Vascular Disease Systematic Review of 40 Studies Involving 58,000 Participants [J].

Erqou, Sebhat ;

Thompson, Alexander ;

Di Angelantonio, Emanuele ;

Saleheen, Danish ;

Kaptoge, Stephen ;

Marcovina, Santica ;

Danesh, John .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (19) :2160-2167

[5]

Goldstein JL, ONLINE METABOLIC MOL

[6] Familial hypercholesterolemia: Current treatment options and patient selection for low-density lipoprotein apheresis [J].

Hemphill, Linda C. .

JOURNAL OF CLINICAL LIPIDOLOGY, 2010, 4 (05) :346-349

[7] Hematologic and Hemostatic Changes Induced by Different Columns During LDL Apheresis [J].

Hovland, Anders ;

Hardersen, Randolf ;

Nielsen, Erik Waage ;

Mollnes, Tom Eirik ;

Lappegard, Knut Tore .

JOURNAL OF CLINICAL APHERESIS, 2010, 25 (05) :294-300

[8] Different Inflammatory Responses Induced by Three LDL-Lowering Apheresis Columns [J].

Hovland, Anders ;

Hardersen, Randolf ;

Sexton, Joe ;

Mollnes, Tom Eirik ;

Lappegard, Knut Tore .

JOURNAL OF CLINICAL APHERESIS, 2009, 24 (06) :247-253

[9] Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein(a) levels and prevent major adverse coronary events [J].

Jaeger, Beate R. ;

Richter, Yvonne ;

Nagel, Dorothea ;

Heigl, Franz ;

Vogt, Anja ;

Roeseler, Eberhard ;

Parhofer, Klaus ;

Ramlow, Wolfgang ;

Koch, Michael ;

Utermann, Gerd ;

Labarrere, Carlos A. ;

Seidel, Dietrich .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2009, 6 (03) :229-239

[10] Do we know when and how to lower lipoprotein(a)? [J].

Joshi P.H. ;

Krivitsky E. ;

Qian Z. ;

Vazquez G. ;

Voros S. ;

Miller J. .

Current Treatment Options in Cardiovascular Medicine, 2010, 12 (4) :396-407

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