PP2A: Unveiling a reluctant tumor suppressor

被引:252
作者
Mumby, Marc [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA
关键词
D O I
10.1016/j.cell.2007.06.034
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:21 / 24
页数:4
相关论文
共 17 条
[11]   The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein [J].
Neviani, P ;
Santhanam, R ;
Trotta, R ;
Notari, M ;
Blaser, BW ;
Liu, SJ ;
Mao, H ;
Chang, JS ;
Galietta, A ;
Uttam, A ;
Roy, DC ;
Valtieri, M ;
Bruner-Klisovic, R ;
Caligiuri, MA ;
Bloomfield, CD ;
Marcucci, G ;
Perrotti, D .
CANCER CELL, 2005, 8 (05) :355-368
[12]   Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the Aβ subunit gene [J].
Ruediger, R ;
Pham, HT ;
Walter, G .
ONCOGENE, 2001, 20 (15) :1892-1899
[13]   The tumor suppressor PP2A Aβ regulates the RaIA GTPase [J].
Sablina, Anna A. ;
Chen, Wen ;
Arroyo, Jason D. ;
Corral, Laura ;
Hector, Melissa ;
Bulmer, Sara E. ;
DeCaprio, James A. ;
Hahn, William C. .
CELL, 2007, 129 (05) :969-982
[14]   Identification of V23RalA-Ser194 as a critical mediator for aurora-A-induced cellular motility and transformation by small pool expression screening [J].
Wu, JC ;
Chen, TY ;
Yu, CTR ;
Tsai, SJ ;
Hsu, JM ;
Tang, MJ ;
Chou, CK ;
Lin, WJ ;
Yuan, CJ ;
Huang, CYF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (10) :9013-9022
[15]   Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins [J].
Xing, Yongna ;
Xu, Yanhui ;
Chen, Yu ;
Jeffrey, Philip D. ;
Chao, Yang ;
Lin, Zheng ;
Li, Zhu ;
Strack, Stefan ;
Stock, Jeffry B. ;
Shi, Yigong .
CELL, 2006, 127 (02) :341-353
[16]   Structure of the protein phosphatase 2A holoenzyme [J].
Xu, Yanhui ;
Xing, Yongna ;
Chen, Yu ;
Chao, Yang ;
Lin, Zheng ;
Fan, Eugene ;
Yu, Jong W. ;
Strack, Stefan ;
Jeffrey, Philip D. ;
Shi, Yigong .
CELL, 2006, 127 (06) :1239-1251
[17]   Critical role for SV40 small-t antigen in human cell transformation [J].
Yu, J ;
Boyapati, A ;
Rundell, K .
VIROLOGY, 2001, 290 (02) :192-198