High sensitivity and selectivity of human antibody attachment at the interstices between substrate-bound gold nanoparticles

被引：32

作者：

Hsu, Chuen-Yuan ^{[1
]}

Huang, Jing-Wen ^{[1
]}

Lin, Kuan-Jiuh ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 03期

关键词：

SURFACE-PLASMON RESONANCE; ENHANCED RAMAN-SCATTERING; LABEL-FREE DETECTION; OPTICAL BIOSENSOR; REAL-TIME; SENSORS; FILMS; SPECTROSCOPY; MOLECULES; ARRAYS;

D O I：

10.1039/c0cc04168h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Durable Au-patterning nanostructures with uniform spacing having an average nanoparticle size of 8 nm and an interparticle gap of 11 nm were fabricated using a microwave-plasma oven. Single molecules of immunoglobulin G (IgG) are individually occupied at the space constraints so that the extinction response of localized surface plasmon resonance (LSPR) can be observed when detecting human anti-IgG molecules, affording a detection limit of 66.7 pM.

引用

页码：872 / 874

页数：3

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