Stem cell biology and the plasticity polemic

被引：49

作者：

Quesenberry, PJ ^{[1
]}

Dooner, G ^{[1
]}

Colvin, G ^{[1
]}

Abedi, M ^{[1
]}

机构：

[1] Roger Williams Med Ctr, Adele R Decof Canc Ctr, Dept Res, Providence, RI 02908 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2005年 / 33卷 / 04期

关键词：

D O I：

10.1016/j.exphem.2004.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Characterization of a cord blood derived unrestricted somatic stem cell (USSC) with capacity to differentiate into hematopoietic and nonhematopoietic tissues in the absence of cell fusion has highlighted the great potential of stem cell plasticity. A great variety of stem cell types have been defined and even the most pure marrow stem cells are highly heterogeneous. Data suggest that stem cells may exist in a continuum with continually and reversibly changing phenotype. These cells also possess a capacity to produce lung, liver, skin, and skeletal muscle under conditions of tissue injury. Arguments raised against the significance of adult marrow to nonmarrow conversions including the importance of cell fusion appear fallacious. We are at the beginning of an exciting and burgeoning field of research with great clinical potential. (c) 2005 International Society for Experimental Hematology. Published by Elsevier Inc.

引用

页码：389 / 394

页数：6

共 70 条

[21]

Bradford GB, 1997, EXP HEMATOL, V25, P445

[22]

BRIDDELL RA, 1992, BLOOD, V79, P3159

[23] Failure of bone marrow cells to transdifferentiate into neural cells in vivo [J].

Castro, RF ;

Jackson, KA ;

Goodell, MA ;

Robertson, CS ;

Liu, H ;

Shine, HD .

SCIENCE, 2002, 297 (5585) :1299-1299

[24] The Endoglinpositive Sca-1Positive Rhodaminelow phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells [J].

Chen, CZ ;

Li, L ;

Li, M ;

Lodish, HF .

IMMUNITY, 2003, 19 (04) :525-533

[25]

CIVIN CI, 1990, PROG CLIN BIOL RES, V333, P387

[26]

Colvin GA, 2004, EXP HEMATOL, V32, P62

[27] Intrinsic hematopoietic stem cell/progenitor plasticity: Inversions [J].

Colvin, GA ;

Lambert, JF ;

Moore, BE ;

Carlson, JE ;

Dooner, MS ;

Abedi, M ;

Cerny, J ;

Quesenberry, PJ .

JOURNAL OF CELLULAR PHYSIOLOGY, 2004, 199 (01) :20-31

[28]

deJong MO, 1996, LEUKEMIA, V10, P1813

[29] SELECTIVE ELIMINATION OF IMMUNOLOGICALLY COMPETENT CELLS FROM BONE MARROW AND LYMPHOCYTE CELL MIXTURES .3. IN VITRO TEST FOR DETECTION OF IMMUNOCOMPETENT CELLS IN FRACTIONATED MOUSE SPLEEN CELL SUSPENSIONS AND PRIMATE BONE MARROW SUSPENSIONS [J].

DICKE, KA ;

TRIDENTE, G ;

VANBEKKU.DW .

TRANSPLANTATION, 1969, 8 (04) :422-&

[30] Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo [J].

Goodell, MA ;

Brose, K ;

Paradis, G ;

Conner, AS ;

Mulligan, RC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1797-1806

← 1 2 3 4 5 6 7 →