Clinical studies of the effect of blood storage on patient outcomes

被引：77

作者：

Triulzi, Darrell J. ^{[1
]}

Yazer, Mark H.

机构：

[1] Univ Pittsburgh, Dept Pathol, Div Transfus Med, Pittsburgh, PA 15260 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2010年 / 43卷 / 01期

基金：

加拿大健康研究院;

关键词：

TRANSFUSED RED-CELLS; CRITICALLY-ILL PATIENTS; BYPASS GRAFT-SURGERY; CARDIAC-SURGERY; STORED-BLOOD; COLORECTAL-CANCER; AGE; MORTALITY; MORBIDITY; TIME;

D O I：

10.1016/j.transci.2010.05.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is indisputable that there are numerous biochemical, structural, inflammatory, and physiologic changes in stored red cells, sometimes referred to collectively as the "red cell storage lesion". It remains controversial however whether any of these changes have clinical relevance and actually impact the clinical outcomes in transfused patients. More than 25 published clinical studies have evaluated the effects of red blood cell storage on patient outcomes. The majority of studies are non-randomized observational studies with methodologic limitations described in this review. These studies do however provide equipoise to support the ethical conduct of the large, definitive randomized clinical trials which are now underway. (c) 2010 Published by Elsevier Ltd.

引用

页码：95 / 106

页数：12

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