Toll-like receptors and innate antiviral responses

被引：69

作者：

Vaidya, SA

Cheng, GH ^{[1
]}

机构：

[1] Univ Calif Los Angeles, MSTP Grad Program, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(03)00070-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) have a unique and important role in detecting the presence of pathogenic infection. TLRs can recognize conserved structures from a wide variety of microorganisms, such as bacteria, mycobacteria, spirochetes and yeast. However, they are generally not thought to play a major role in viral infection. Several reports have now identified distinct viral ligands for the TLRs, and evidence is accumulating for a functional role of the TLRs in mediating antiviral effector mechanisms.

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页码：402 / 407

页数：6

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