Endogenous DNA damage and mutation

被引：133

作者：

Marnett, LJ ^{[1
]}

Plastaras, JP ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem,Ctr Mol Toxicol, Vanderbilt Ingram Canc Ctr,AB Hancock Jr Mem Lab, Nashville, TN 37232 USA

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(01)02239-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In humans, approximately 10(7) cells divide per second. Estimates suggest that spontaneous mutations arise in about a third of those cells. These mutations arise as mistakes in DNA replication and when DNA polymerases copy damaged templates. The latter result from chemical hydrolysis of nucleoside bases or by reaction of DNA with electrophiles or reactive free radicals generated during metabolism (endogenous DNA damaging agents). This article highlights recent discoveries and emerging opportunities in the study of endogenous DNA damage and mutation.

引用

页码：214 / 221

页数：8

共 90 条

[61]

Nair J, 1998, CANCER EPIDEM BIOMAR, V7, P435

[62]

Nair J, 1997, CANCER EPIDEM BIOMAR, V6, P597

[63] Promutagenic etheno-DNA adducts in multistage mouse skin carcinogenesis:: Correlation with lipoxygenase-catalyzed arachidonic acid metabolism [J].