Water-soluble 99mTc-labeled dendritic novel porphyrins tumor imaging and diagnosis

被引：30

作者：

Subbarayan, M

Shetty, SJ

Srivastava, TS

Noronha, OPD

Samuel, AM

Mukhtar, H

机构：

[1] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA

[2] Bhabha Atom Res Ctr, Radiat Med Ctr, Bombay 400012, Maharashtra, India

[3] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 01期

关键词：

Tc-99m-labeled dendritic porphyrin; scintiimaging; photodynamic therapy; photodynamic diagnosis;

D O I：

10.1006/bbrc.2001.4289

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeIed them with Tc-99m. These Tc-99m-labeled porphyrins were administered to C-6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications. (C) 2001 Academic Press.

引用

页码：32 / 36

页数：5

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