Serological hint suggesting that Parachlamydiaceae are agents of pneumonia in polytraumatized intensive care patients

被引:54
作者
Greub, G
Boyadjiev, I
La Scola, B
Raoult, D
Martin, C
机构
[1] Hop Nord Marseille, Unite Rickettsies, Fac Med, Marseille, France
[2] Hop Nord Marseille, Dept Anesthesie Reanimat, Marseille, France
来源
RICKETTSIOLOGY: PRESENT AND FUTURE DIRECTIONS | 2003年 / 990卷
关键词
Parachlamydiaceae; intensive care patients; pneumonia; serology;
D O I
10.1111/j.1749-6632.2003.tb07381.x
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Parachlamydiaceae are potential emerging pathogens that naturally infect free-living amoebae. Intensive-care patients are highly exposed to aerosols and, consequently, exposed to free-living amoebae and to their intracellular hosts. Thus, we tested intensive-care patients for antibodies to Parachlamydia and determined if serum reactivity was associated with pneumonia. Patients who underwent intubation and were hospitalized in our intensive-care unit were eligible. Clinical data and serum were recorded prospectively. Seventy-three sera taken from 37 intensive-care patients and 100 sera from healthy blood donors were tested for reactivity against Parachlamydia by immunofluorescence. We detected an antibody titer greater than or equal to 1:100 in 5 out of 37 intensive-care unit patients (13.5%), including three seroconversions (8.1%). By contrast, no blood donors were reactive against Parachlamydia (P<0.001). All patients with serological evidence of a recent exposure to Parachlamydia were trauma patients with head injury and aspiration pneumonia. Moreover, both patients with serological evidence of previous exposure to Parachlamydia were admitted for a cerebral hemorrhage. This serological study suggests that Parachlamydiaceae are associated with aspiration pneumonia in trauma patients admitted to intensive-care units.
引用
收藏
页码:311 / 319
页数:9
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