Interleukin 6 as a Key Regulator of Muscle Mass during Cachexia

被引：173

作者：

Carson, James A. ^{[1
]}

Baltgalvis, Kristen A. ^{[1
]}

机构：

[1] Univ S Carolina, Div Appl Physiol, Dept Exercise Sci, Integrat Muscle Biol Lab, Columbia, SC 29208 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2010年 / 38卷 / 04期

基金：

美国国家卫生研究院;

关键词：

colon cancer; wasting; inflammation; atrogin; 1; exercise; CANCER CACHEXIA; APC(MIN/+) MICE; PHYSICAL-ACTIVITY; EXERCISE; IL-6; ATROPHY; GROWTH; MOUSE; RATS; METABOLISM;

D O I：

10.1097/JES.0b013e3181f44f11

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

CARSON, J.A. and K. A. BALTGALVIS. Interleukin 6 as a key regulator of muscle mass during cachexia. Exerc. Sport Sci. Rev., Vol. 38, No. 4, pp. 168Y176, 2010. Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the indirect actions of IL-6 that may cause muscle wasting.

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页码：168 / 176

页数：9

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