Vaccines for the prevention of HIV-1 disease

被引：51

作者：

Mascola, JR ^{[1
]}

Nabel, GJ ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00246-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical investigation in humans and experimental lentivirus infection in nonhuman primates have advanced our understanding of immune responses that control HIV-1 disease. Recently, immunization approaches in macaques have shown that the immune response can control viremia and improve clinical outcome. When such vaccine strategies are formulated to be similarly immunogenic in humans, they could form the basis for the development of candidate AIDS vaccines that would prevent infection. suppress progression to disease or reduce HIV-1 transmission in humans.

引用

页码：489 / 495

页数：7