Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes

被引：48

作者：

Roy, Noemi B. A. ^{[1
]}

Myerson, Saul ^{[2
]}

Schuh, Anna H. ^{[3
]}

Bignell, Patricia ^{[3
]}

Patel, Roger ^{[4
]}

Wainscoat, Jim S. ^{[5
]}

McGowan, Simon ^{[6
]}

Marchi, Emanuele ^{[6
]}

Atoyebi, Wale ^{[5
]}

Littlewood, Tim ^{[5
]}

Chacko, Joseph ^{[7
]}

Vyas, Paresh

Killick, Sally B. ^{[7
]}

机构：

[1] John Radcliffe Hosp, Weatherall Inst Mol Med, Mol Haematol Unit, Oxford OX3 9DS, England

[2] Oxford Radcliffe Hosp, Dept Cardiol, Oxford, England

[3] Oxford Radcliffe Hosp, Haemato Mol Diagnost Serv, Oxford, England

[4] Royal Bournemouth Hosp, Dept Radiol, Bournemouth, Dorset, England

[5] Oxford Radcliffe Hosp, Dept Haematol, Oxford, England

[6] Weatherall Inst Mol Med, Computat Biol Res Grp, Oxford, England

[7] Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 154卷 / 04期

关键词：

myelodysplastic syndromes; magnetic resonance imaging; transfusional iron overload; hepatic R2*; cardiac R2*; MAGNETIC-RESONANCE; MYOCARDIAL IRON; ACQUIRED ANEMIAS; THALASSEMIA; CHELATION; DISEASE;

D O I：

10.1111/j.1365-2141.2011.08749.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transfusion- dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16.8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r = 0.72, P < 0.0001) and ferritin (r = 0.53, P < 0.0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53.7 x 10(5) Megaunits vs. 12.2 x 10(5) Megaunits, P = 0.002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients.

引用

页码：521 / 524

页数：4