Comparison between the first and second generation bioresorbable vascular scaffolds: a six month virtual histology study

被引：13

作者：

Brugaletta, Salvatore ^{[1
]}

Garcia-Garcia, Hector M. ^{[1
]}

Diletti, Roberto ^{[1
]}

Gomez-Lara, Josep ^{[1
]}

Garg, Scot ^{[1
]}

Onuma, Yoshinobu ^{[1
]}

Shin, Eun-Seok ^{[1
]}

van Geuns, Robert Jan ^{[1
]}

de Bruyne, Bernard

Dudek, Dariusz ^{[2
]}

Thuesen, Leif ^{[3
]}

Chevalier, Bernard ^{[4
]}

McClean, Dougal ^{[5
]}

Windecker, Stephan ^{[6
]}

Whitbourn, Robert ^{[7
]}

Dorange, Cecile ^{[9
]}

Veldhof, Susan ^{[9
]}

Rapoza, Richard ^{[8
]}

Sudhir, Krishnankutty ^{[8
]}

Bruining, Nico ^{[1
]}

Ormiston, John A. ^{[1
]}

Serruys, Patrick W. ^{[1
]}

机构：

[1] Erasmus MC, Thoraxctr, NL-3015 NE Rotterdam, Netherlands

[2] Jagiellonian Univ, Dept Cardiol, Krakow, Poland

[3] Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol, Skejby, Denmark

[4] Inst Hosp Jacques Cartier, Dept Cardiol, Massy, France

[5] Christchurch Hosp, Dept Cardiol, Christchurch, New Zealand

[6] Univ Hosp Bern, Dept Cardiol, Bern, Switzerland

[7] St Vincents Hosp, Dept Cardiol, Fitzroy, Vic, Australia

[8] Abbott Vasc, Santa Clara, CA USA

[9] Abbott Vasc, Diegem, Belgium

来源：

EUROINTERVENTION | 2011年 / 6卷 / 09期

关键词：

Bioresorbable vascular scaffold; intravascular ultrasound virtual histology; ELUTING CORONARY STENT; ABSORB; IMPLANTATION; ABSORPTION; RECOIL; SYSTEM;

D O I：

10.4244/EIJV6I9A193

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To compare the intravascular ultrasound virtual histology (IVUS-VH) appearance of the polymeric struts of the first (Revision 1.0) and the second (Revision 1.1) generation bioresorbable vascular scaffold (BVS). Methods and results: IVUS-VH misrepresents polymeric struts as dense calcium (DC) and necrotic core (NC) so that their presence and disappearance could be used as potential artifactual surrogate of bioresorption. DC and NC were assessed in both revisions of the BVS by analysing IVUS-VH from all patients in the ABSORB cohort A (Revision 1.0) and cohort B (Revision 1.1) study who had an IVUS-VH post-treatment and at 6-month follow-up. Post-treatment and 6-month follow-up IVUS-VH results, available in 60 patients (BVS 1.0 n=28; BVS 1.1 n=32), indicated an insignificant rise in DC+NC area compared to baseline with Revision 1.1 (0.10 +/- 0.46 mm(2), p=0.2), whilst a significant reduction was seen with Revision 1.0 (-0.57 +/- 1.3 mm(2), p=0.02). A significant correlation has been found between the change in the DC+NC area and the change in external elastic membrane area (y=0.68x-0.1; r=0.58, p=0.03). Conclusions: Based on 6-months IVUS-VH analysis, the BVS 1.1 appears to have a different backscattering signal compared to the BVS 1.0, which may reflect differences in the speed of chemical and structural alteration.

引用

页码：1110 / 1116

页数：7

共 15 条

[1] Monitoring In Vivo Absorption of a Drug-Eluting Bioabsorbable Stent With Intravascular Ultrasound-Derived Parameters A Feasibility Study [J].

Bruining, Nico ;

de Winter, Sebastiaan ;

Roelandt, Jos R. T. C. ;

Regar, Evelyn ;

Heller, Iddo ;

van Domburg, Ron T. ;

Hamers, Ronald ;

Onuma, Yoshinobu ;

Dudek, Darius ;

Webster, Mark W. I. ;

Thuesen, Leif ;

Ormiston, John A. ;

Cheong, Wai-Fung ;

Miguel-Hebert, Karine ;

Veldhof, Susan ;

Serruys, Patrick W. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2010, 3 (04) :449-456

[2] Assessment of the absorption process following bioabsorbable everolimus-eluting stent implantation: temporal changes in strain values and tissue composition using intravascular ultrasound radiofrequency data analysis A substudy of the ABSORB clinical trial [J].

Garcia-Garcia, Hector M. ;

Gonzalo, Nieves ;

Pawar, Ravindra ;

Kukreja, Neville ;

Dudek, Dariusz ;

Thuesen, Leif ;

Ormiston, John A. ;

Regar, Evelyn ;

Serruys, Patrick W. .

EUROINTERVENTION, 2009, 4 (04) :443-448

[3] The Virtual Histology Intravascular Ultrasound Appearance of Newly Placed Drug-Eluting Stents [J].

Kim, Sang-Wook ;

Mintz, Gary S. ;

Hong, Young-Joon ;

Pakala, Rajbabu ;

Park, Kyung-Sook ;

Pichard, Augusto D. ;

Satler, Lowell F. ;

Kent, Kenneth M. ;

Suddath, William O. ;

Waksman, Ron ;

Weissman, Neil J. .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 102 (09) :1182-1186

[4] Arterial remodeling after coronary angioplasty - A serial intravascular ultrasound study [J].

Mintz, GS ;

Popma, JJ ;

Pichard, AD ;

Kent, KM ;

Satler, LF ;

Wong, SC ;

Hong, MK ;

Kovach, JA ;

Leon, MB .

CIRCULATION, 1996, 94 (01) :35-43

[5] Coronary plaque classification with intravascular ultrasound radiofrequency data analysis [J].

Nair, A ;

Kuban, BD ;

Tuzcu, EM ;

Schoenhagen, P ;

Nissen, SE ;

Vince, DG .

CIRCULATION, 2002, 106 (17) :2200-2206

[6] Accuracy of in vivo coronary plaque morphology assessment - A validation study of in vivo virtual histology compared with in vitro histopathology [J].

Nasu, Kenya ;

Tsuchikane, Etsuo ;

Katoh, Osamu ;

Vince, D. Geoffrey ;

Virmani, Renu ;

Surmely, Jean-Francois ;

Murata, Akira ;

Takeda, Yoshihiro ;

Ito, Tatsuya ;

Ehara, Mariko ;

Matsubara, Tetsuo ;

Terashima, Mitsuyasu ;

Suzuki, Takahiko .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (12) :2405-2412

[7]

Okamura T, 2010, EUROINTERVENTION, V5, P932, DOI 10.4244/

[8] A bioabsorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB): a prospective open-label trial [J].

Ormiston, John A. ;

Serruys, Patrick W. ;

Regar, Evelyn ;

Dudek, Dariusz ;

Thuesen, Leif ;

Webster, Mark W. I. ;

Onuma, Yoshinobu ;

Garcia-Garcia, Hector M. ;

McGreevy, Robert ;

Veldhof, Susan .

LANCET, 2008, 371 (9616) :899-907

[9] First-in-human implantation of a fully bioabsorbable drug-eluting stent: The BVS poly-L-lactic acid everolimus-eluting coronary stent [J].

Ormiston, John A. ;

Webster, Mark W. I. ;

Armstrong, Guy .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2007, 69 (01) :128-131

[10] IVUS Radiofrequency Analysis in the Evaluation of the Polymeric Struts of the Bioabsorbable Everolimus-Eluting Device During the Bioabsorption Process [J].

Sarno, Giovanna ;

Onuma, Yoshinobu ;

Garcia, Hector M. Garcia ;

Garg, Scot ;

Regar, Evelyn ;

Thuesen, Leif ;

Dudek, Dariusz ;

Veldhof, Susan ;

Dorange, Cecile ;

Ormiston, John A. ;

Serruys, Patrick W. .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2010, 75 (06) :914-918

← 1 2 →