In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration

被引：185

作者：

Liu, Li ^{[1
]}

Gao, Qi ^{[2
]}

Lu, Xuemin ^{[1
]}

Zhou, Huifang ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Dongchuan Rd 800, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Biomed Engn, Dongchuan Rd 800, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Zhizaoju Rd 639, Shanghai 200011, Peoples R China

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 11卷 / 06期

关键词：

In situ gel; Sol-gel transition; Chitosan; Drug delivery; Tissue regeneration; BIOMEDICAL APPLICATIONS; THERMOSENSITIVE HYDROGEL; GLYCEROPHOSPHATE HYDROGEL; INJECTABLE HYDROGEL; VIVO EVALUATION; GEL SYSTEM; FORMULATION; GELATION; VITRO; DERIVATIVES;

D O I：

10.1016/j.ajps.2016.07.001

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In situ forming hydrogels with simple sol-gel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration. State-of-the-art in situ gelling systems can easily and efficiently be formed by different mechanisms in situ. Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical applications due to its good biocompatibility, low immunogenicity and specific biological activities. Chitosan-based in situ gelling systems have already gained much attention as smart biomaterials in the development of several biomedical applications, such as for drug delivery systems and regeneration medicine. Herein, we review the typical in situ gelling systems based on chitosan and mechanisms involved in hydrogel forming, and report advances of chitosan-based in situ gels for the applications in drug delivery and tissue regeneration. Finally, development prospects of in situ forming hydrogels based on chitosan are also discussed in brief. (C) 2016 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.

引用

页码：673 / 683

页数：11

共 85 条

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Preformed chitosan cryogel-biphasic calcium phosphate: a potential injectable biocomposite for pathologic fracture [J].