Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy

被引：60

作者：

van Loevezijn, A

van Maarseveen, JH

Stegman, K

Visser, GM

Koomen, GJ

机构：

[1] Univ Amsterdam, Inst Mol Chem, Organ Chem Lab, NL-1018 WS Amsterdam, Netherlands

[2] Solvay Pharmaceut Res Labs, NL-1380 DA Weesp, Netherlands

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期

关键词：

solid-phase synthesis; Pictet-Spengler reactions; amino acids and derivatives; coupling reagents;

D O I：

10.1016/S0040-4039(98)00931-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solid phase synthesis towards structural analogs of fumitremorgins, verruculogens and tryprostatins using a cyclization/cleavage strategy was developed. To prove the general applicability of the route, a representative set of 42 single compounds (as diastereomeric mixtures) was prepared by parallel synthesis and analyzed with LC/MS. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4737 / 4740

页数：4

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