Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus

被引：4

作者：

Inamura, N ^{[1
]}

Nawa, H ^{[1
]}

Takei, N ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Dept Mol Neurobiol, Niigata 9518585, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 346卷 / 1-2期

基金：

日本学术振兴会;

关键词：

translation; initiation; development; aging; protein synthesis; brain;

D O I：

10.1016/S0304-3940(03)00592-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regulated protein synthesis is critical for neural development, such as the formation of synapses and neural circuits and the modulation of synaptic plasticity. Protein synthesis is controlled by translation factors, including initiation, elongation and release factors. Here we investigated the developmental changes of eukaryotic initiation factor 213 (eIF2B) subunits in rat hippocampus. The eIF2B beta, gamma, delta and epsilon subunit protein levels were maximal at embryonic day 18 and then decreased during development. Aged hippocampus contained only trace amounts of these subunits. The finding that eIF2B subunit levels are high in developing hippocampus suggests that regulated protein synthesis is active in young, highly plastic brain. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 119

页数：3

共 14 条

[1] DEVELOPMENTAL STUDIES OF THE 1ST STEP OF THE INITIATION OF BRAIN PROTEIN-SYNTHESIS, ROLE FOR INITIATION FACTOR-II [J].

CALES, C ;

LFANDO, J ;

AZUARA, C ;

SALINAS, M .

MECHANISMS OF AGEING AND DEVELOPMENT, 1986, 33 (02) :147-156

[2] PROTEIN-SYNTHESIS AND MEMORY - A REVIEW [J].

DAVIS, HP ;

SQUIRE, LR .

PSYCHOLOGICAL BULLETIN, 1984, 96 (03) :518-559

[3] A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation [J].

Fogli, A ;

Dionisi-Vici, C ;

Deodato, F ;

Bartuli, A ;

Boespflug-Tanguy, O ;

Bertini, E .

NEUROLOGY, 2002, 59 (12) :1966-1968

[4] Internal ribosome entry sites in eukaryotic mRNA molecules [J].

Hellen, CUT ;

Sarnow, P .

GENES & DEVELOPMENT, 2001, 15 (13) :1593-1612

[5]

Hershey JWB, 2000, COLD SPRING HARBOR M, V39, P33

[6]

Hinnebusch AG, 2000, COLD SPRING HARBOR M, V39, P185

[7] Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus [J].

Inamura, N ;

Hoshino, S ;

Uchiumi, T ;

Nawa, H ;

Takei, N .

MOLECULAR BRAIN RESEARCH, 2003, 111 (1-2) :165-174

[8] AGE-DEPENDENT DECREASE IN THE AMOUNT OF EUKARYOTIC INITIATION FACTOR-II IN VARIOUS RAT-TISSUES [J].

KIMBALL, SR ;

VARY, TC ;

JEFFERSON, LS .

BIOCHEMICAL JOURNAL, 1992, 286 :263-268

[9] Synaptic plasticity in cortical systems [J].

Klintsova, AY ;

Greenough, WT .

CURRENT OPINION IN NEUROBIOLOGY, 1999, 9 (02) :203-208

[10] Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter [J].

Leegwater, PAJ ;

Vermeulen, G ;

Könst, AAM ;

Naidu, S ;

Mulders, J ;

Visser, A ;

Kersbergen, P ;

Mobach, D ;

Fonds, D ;

van Berkel, CGM ;

Lemmers, RJLF ;

Frants, RR ;

Oudejans, CBM ;

Schutgens, RBH ;

Pronk, JC ;

van der Knaap, MS .

NATURE GENETICS, 2001, 29 (04) :383-388

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