Host genetics of mycobacterial diseases in mice and men: Forward genetic studies of BCG-osis and tuberculosis

被引：135

作者：

Fortin, A. ^{[1
]}

Abel, L.

Casanova, J. L.

Gros, P.

机构：

[1] Emerillon Therapeut, Montreal, PQ H3A 1L2, Canada

[2] Univ Paris, Fac Med, Lab Human Genet Infect Dis, F-75015 Paris, France

[3] INSERM, U550, Paris, France

[4] Hop Necker Enfants Malad, Pediat Hematol Immunol Unit, F-75015 Paris, France

[5] McGill Univ, Ctr Host Resistance, Dept Biochem, Montreal, PQ, Canada

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2007年 / 8卷

关键词：

mycobacteria; for-ward genetics; genes; loci; human; mouse strains; infectious diseases;

D O I：

10.1146/annurev.genom.8.080706.092315

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In humans, genetic factors have long been suspected to contribute to the onset and outcome of tuberculosis. Such effects are difficult to identify owing to their complex inheritance, and to the confounding impact of environmental factors, notably pathogen-associated virulence determinants. Recently, forward genetic approaches in mouse models and in human populations have been used to elucidate a molecular basis for predisposition to mycobacterial diseases. The genetic dissection of host predisposition to infection with Mycobacterium bovis BCG and M. tuberculosis will help to define the key molecules involved in host antituberculous immunity and should provide new insights into this important infectious disease.

引用

页码：163 / 192

页数：30

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