Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

被引：103

作者：

Ding, Dan ^{[1
]}

Li, Kai ^{[1
]}

Zhu, Zhenshu ^{[3
,4
]}

Pu, Kan-Yi ^{[1
]}

Hu, Yong ^{[2
]}

Jiang, Xiqun ^{[3
,4
]}

Liu, Bin ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

[2] Nanjing Univ, Natl Lab Solid State Microstruct, Dept Mat Sci & Engn, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Coll Chem & Chem Engn, Lab Mesoscop Chem, Nanjing 210093, Peoples R China

[4] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China

来源：

NANOSCALE | 2011年 / 3卷 / 05期

基金：

中国国家自然科学基金;

关键词：

GLYCOL CHITOSAN NANOPARTICLES; WALLED CARBON NANOTUBES; MRI CONTRAST AGENT; QUANTUM DOTS; LOADED NANOPARTICLES; OXIDE NANOPARTICLES; IRON-OXIDE; MICE; POLYMER; DELIVERY;

D O I：

10.1039/c0nr00950d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE-PEG-Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivo drug distribution in nude mice upon intravenous administration.

引用

页码：1997 / 2002

页数：6

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