Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pKa values of zwitterionic drugs in acetonitrile-water mixtures

被引：106

作者：

Barbosa, J ^{[1
]}

Barrón, D ^{[1
]}

Jiménez-Lozano, E ^{[1
]}

Sanz-Nebot, V ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

ANALYTICA CHIMICA ACTA | 2001年 / 437卷 / 02期

关键词：

zwitterionic quinolones; acid dissociation constant; capillary electrophoresis; liquid chromatography; potentiometry; UV-visible spectrophotometry;

D O I：

10.1016/S0003-2670(01)00997-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis, liquid chromatography, potentiometry and UV-visible spectrophotometry are frequently used for determination of pK(a) values of substances. In this work, we have compared the application of the different techniques to the determination of pK(a) values of a series of zwitterionic quinolones in acetonitrile-water mixtures, emphasizing the advantages of capillary electrophoresis for the determination of equilibrium constants of widely used drugs in aqueous and organic media. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：309 / 321

页数：13

共 49 条

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