Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pKa values of zwitterionic drugs in acetonitrile-water mixtures

被引：106

作者：

Barbosa, J ^{[1
]}

Barrón, D ^{[1
]}

Jiménez-Lozano, E ^{[1
]}

Sanz-Nebot, V ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

ANALYTICA CHIMICA ACTA | 2001年 / 437卷 / 02期

关键词：

zwitterionic quinolones; acid dissociation constant; capillary electrophoresis; liquid chromatography; potentiometry; UV-visible spectrophotometry;

D O I：

10.1016/S0003-2670(01)00997-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis, liquid chromatography, potentiometry and UV-visible spectrophotometry are frequently used for determination of pK(a) values of substances. In this work, we have compared the application of the different techniques to the determination of pK(a) values of a series of zwitterionic quinolones in acetonitrile-water mixtures, emphasizing the advantages of capillary electrophoresis for the determination of equilibrium constants of widely used drugs in aqueous and organic media. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：309 / 321

页数：13

共 49 条

[41] REFERENCE VALUE STANDARDS AND PRIMARY STANDARDS FOR PH MEASUREMENTS IN ORGANIC-SOLVENTS AND WATER + ORGANIC-SOLVENT MIXTURES OF MODERATE TO HIGH PERMITTIVITIES
RONDININI, S
MUSSINI, PR
MUSSINI, T
[J]. PURE AND APPLIED CHEMISTRY, 1987, 59 (11) : 1549 - 1560
[42] NONAQUEOUS CAPILLARY ELECTROPHORESIS
SAHOTA, RS
KHALEDI, MG
[J]. ANALYTICAL CHEMISTRY, 1994, 66 (07) : 1141 - 1146
[43] Influence of organic solvents on the separation selectivity in capillary electrophoresis
Sarmini, K
Kenndler, E
[J]. JOURNAL OF CHROMATOGRAPHY A, 1997, 792 (1-2) : 3 - 11
[44] SHEROOD PH, 1997, NLREG PROGRAM
[45] A NEW LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF ACID DISSOCIATION-CONSTANTS
SHIBUKAWA, M
AOKI, K
OGUMA, K
[J]. ANALYTICAL SCIENCES, 1995, 11 (06) : 915 - 922
[46] OPTIMIZATION OF PH FOR THE SEPARATION OF ORGANIC-ACIDS IN CAPILLARY ZONE ELECTROPHORESIS
SMITH, SC
KHALEDI, MG
[J]. ANALYTICAL CHEMISTRY, 1993, 65 (03) : 193 - 198
[47] Interactions of basic compounds in reversed-phase high-performance liquid chromatography - Influence of sorbent character, mobile phase composition, and pH on retention of basic compounds
Sykora, D
Tesarova, E
Popl, M
[J]. JOURNAL OF CHROMATOGRAPHY A, 1997, 758 (01) : 37 - 51
[48] PROTONATION EQUILIBRIA OF QUINOLONE ANTIBACTERIALS
TAKACSNOVAK, K
NOSZAL, B
HERMECZ, I
KERESZTURI, G
PODANYI, B
SZASZ, G
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (11) : 1023 - 1028
[49] Behavior and use of nonaqueous media without supporting electrolyte in capillary electrophoresis and capillary electrochromatography
Wright, PB
Lister, AS
Dorsey, JG
[J]. ANALYTICAL CHEMISTRY, 1997, 69 (16) : 3251 - 3259

← 1 2 3 4 5 →