Age-associated alteration in naive and memory Th17 cell response in humans

被引：62

作者：

Lee, Jin Soo ^{[1
,2
]}

Lee, Won-Woo ^{[1
,3
]}

Kim, Sang Hyun ^{[1
,4
]}

Kang, Youna ^{[1
]}

Lee, Naeun ^{[1
]}

Shin, Min Sun ^{[1
]}

Kang, Seong Wook ^{[1
,5
]}

Kang, Insoo ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06520 USA

[2] Inha Univ, Sch Med, Dept Internal Med, Inchon 400712, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Microbiol, Seoul 110799, South Korea

[4] Kangwon Natl Univ, Coll Med, Dept Microbiol, Chunchon 200701, Kangwon Do, South Korea

[5] Chungnam Natl Univ, Coll Med, Dept Internal Med, Taejon 301131, South Korea

来源：

CLINICAL IMMUNOLOGY | 2011年 / 140卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Human; Aging; IL-17; T helper 17 (Th17) cells; CD4+T cells; COMMUNITY-ACQUIRED PNEUMONIA; T-CELLS; HOST-DEFENSE; IL-17; EXPRESSION; DIFFERENTIATION; INTERLEUKIN-17; REQUIREMENT; FREQUENCY; CHEMOKINE;

D O I：

10.1016/j.clim.2011.03.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age >= 65) had a decreased frequency of IL-17-producing cells in memory CD4(+) T cells compared to healthy young people (age <= 40) while both groups had similar frequencies of IFN-gamma-producing cells in the same memory cell subset as measured by flow cytometry. In contrast, the healthy elderly had increased differentiation of IL-17-producing effector cells but not IFN-gamma-producing cells from naive CD4(+) T cells compared to the healthy young. The results of ELISA also showed similar findings with increased IL-17 production from naive CD4(+) T cells and decreased IL-17 production from memory CD4(+) T cells in the elderly compared to the young. These findings indicate that aging differentially affects naive and memory Th17 cell responses in humans. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：84 / 91

页数：8

共 34 条

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