Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex

被引：77

作者：

Kumari, V ^{[1
]}

Gray, JA ^{[1
]}

机构：

[1] Univ London, Inst Psychiat, Dept Psychol, Sect Cognit Psychopharmacol, London SE5 8AF, England

来源：

PSYCHOPHARMACOLOGY | 1999年 / 141卷 / 01期

关键词：

prepulse inhibition; acoustic startle reflex; smelting withdrawal; nicotine dependence;

D O I：

10.1007/s002130050800

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the relationship between nicotine dependence as measured by the Fagerstrom Tolerance Questionnaire (FTQ) and prepulse inhibition (PPI) of the acoustic startle reflex measured after overnight smoking withdrawal in a non-clinical population of male smokers with no history of psychiatric disorders or drug/alcohol abuse. It was found that smokers who scored high (>median) on the FTQ showed significantly less PPI as compared to those scoring low (<median) on this scale. This finding further supports a role for nicotine in modulation of PPI, as has previously been found in rats and also in human beings.

引用

页码：11 / 15

页数：5

共 34 条

[21] Effect of acute subcutaneous nicotine on prepulse inhibition of the acoustic startle reflex in healthy male non-smokers [J].

Kumari, V ;

Cotter, PA ;

Checkley, SA ;

Gray, JA .

PSYCHOPHARMACOLOGY, 1997, 132 (04) :389-395

[22] Habituation and prepulse inhibition of the acoustic startle reflex: Effects of smoking status and psychosis-proneness [J].

Kumari, V ;

Toone, B ;

Gray, JA .

PERSONALITY AND INDIVIDUAL DIFFERENCES, 1997, 23 (02) :183-191

[23] ALTERATIONS IN OTHER SENSORY MODALITIES ACCOMPANYING STRESS ANALGESIA AS MEASURED BY STARTLE REFLEX MODIFICATION [J].

LEITNER, DS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 467 :82-92

[24]

Norris CM, 1996, PSYCHOBIOLOGY, V24, P160

[25] NICOTINE DEPENDENCE IN CIGARETTE-SMOKING - AN EMPIRICALLY-BASED, MULTIVARIATE MODEL [J].

POMERLEAU, OF ;

FERTIG, JB ;

SHANAHAN, SO .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 19 (02) :291-299

[26] MULTIPLE SEROTONIN RECEPTOR SUBTYPES MODULATE PREPULSE INHIBITION OF THE STARTLE RESPONSE IN RATS [J].

SIPES, TA ;

GEYER, MA .

NEUROPHARMACOLOGY, 1994, 33 (3-4) :441-448

[27] 8-OH DPAT DISRUPTION OF PREPULSE INHIBITION IN RATS - REVERSAL WITH (+)WAY-100,135 AND LOCALIZATION OF SITE OF ACTION [J].

SIPES, TA ;

GEYER, MA .

PSYCHOPHARMACOLOGY, 1995, 117 (01) :41-48

[28]

Sipes TE, 1995, BEHAV PHARMACOL, V6, P839

[29]

SWERDLOW NR, 1994, ARCH GEN PSYCHIAT, V51, P139

[30] A PRELIMINARY ASSESSMENT OF SENSORIMOTOR GATING IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER [J].

SWERDLOW, NR ;

BENBOW, CH ;

ZISOOK, S ;

GEYER, MA ;

BRAFF, DL .

BIOLOGICAL PSYCHIATRY, 1993, 33 (04) :298-301

← 1 2 3 4 →