Local elastic properties of cells studied by SFM

被引：42

作者：

Lekka, M

Lekki, J

Marszalek, M

Golonka, P

Stachura, Z

Cleff, B

Hrynkiewicz, AZ

机构：

[1] Inst Nucl Phys, PL-31342 Krakow, Poland

[2] Univ Munster, Inst Nucl Phys, D-4400 Munster, Germany

来源：

APPLIED SURFACE SCIENCE | 1999年 / 141卷 / 3-4期

关键词：

scanning force microscopy (SFM); methodology; elasticity; normal cells; cancerous cells;

D O I：

10.1016/S0169-4332(98)00522-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Scanning force microscopy (SFM) can be used in nano-indentation experiments for very soft samples of elastic, organic materials. The present paper describes the methodology of device calibration and Young's moduli determination, to evaluate the elastic properties of living cells in their culture conditions. Two similar lines of normal cells (Hu609) and cancerous ones (T24) were measured. A significant difference in Young's modulus for normal and cancerous cells was detected. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：345 / 349

页数：5

共 9 条

[1] Cytoskeletal and adhesion proteins as tumor suppressors [J].