Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

被引：1236

作者：

Wu, Gang ^{[2
]}

Broniscer, Alberto ^{[3
]}

McEachron, Troy A. ^{[4
]}

Lu, Charles ^{[1
]}

Paugh, Barbara S. ^{[4
]}

Becksfort, Jared ^{[5
]}

Qu, Chunxu ^{[5
]}

Ding, Li ^{[1
]}

Huether, Robert ^{[2
]}

Parker, Matthew ^{[2
]}

Zhang, Junyuan ^{[4
]}

Gajjar, Amar ^{[3
]}

Dyer, Michael A. ^{[4
]}

Mullighan, Charles G. ^{[6
]}

Gilbertson, Richard J. ^{[4
]}

Mardis, Elaine R. ^{[1
]}

Wilson, Richard K. ^{[1
]}

Downing, James R. ^{[6
]}

Ellison, David W. ^{[6
]}

Zhang, Jinghui ^{[2
]}

Baker, Suzanne J. ^{[4
]}

机构：

[1] Washington Univ, Sch Med, Genome Inst, St Louis, MO 63130 USA

[2] St Jude Childrens Res Hosp, Dept Computat Biol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[5] St Jude Childrens Res Hosp, Hartwell Ctr Biotechnol & Bioinformat, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng.1102

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p. Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p. Gly34Arg alteration.

引用

页码：251 / 253

页数：3

共 14 条

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