NASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages

被引：81

作者：

Bieghs, Veerle ^{[1
]}

Rensen, Patrick C. N. ^{[2
]}

Hofker, Marten H. ^{[3
]}

Shiri-Sverdlov, Ronit ^{[1
]}

机构：

[1] Maastricht Univ, Dept Mol Genet, NL-6200 MD Maastricht, Netherlands

[2] Leiden Univ, Med Ctr, Dept Gen Internal Med Endocrinol & Metab Dis, Leiden, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Lab Med, NL-9700 AB Groningen, Netherlands

来源：

ATHEROSCLEROSIS | 2012年 / 220卷 / 02期

关键词：

Non-alcoholic steatohepatitis (NASH); Steatosis; Macrophages; Kupffer cells; Atherosclerosis; Foam cells; FATTY LIVER-DISEASE; FARNESOID-X-RECEPTOR; INDUCED NONALCOHOLIC STEATOHEPATITIS; HIGH-DENSITY-LIPOPROTEIN; ARTERY WALL THICKNESS; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; E-KNOCKOUT MICE; ENDOTHELIAL DYSFUNCTION; URSODEOXYCHOLIC ACID;

D O I：

10.1016/j.atherosclerosis.2011.08.041

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophage infiltration into the atherosclerotic lesion is known to play a central role in the initiation of atherosclerosis. In contrast, the role of macrophages during the etiology of non-alcoholic steatohepatitis (NASH) has been considered to be merely a late consequence of steatosis. However, recent insights suggest that macrophage activation and infiltration is also an early initiating event in NASH and thereby point to the shared etiology of atherosclerosis and NASH. In this review, we put forward the hypothesis that NASH and atherosclerosis are actually two aspects of a shared disease, involving the local presence of activated macrophages. We will review the current data supporting the shared mechanisms and also discuss the implications. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：287 / 293

页数：7

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