Viral-based gene transfer to the mammalian CNS for functional genomic studies

被引：37

作者：

Janson, CG

McPhee, SWJ

Leone, P

Freese, A

During, MJ

机构：

[1] Jefferson Med Coll, CNS Gene Therapy Ctr, Philadelphia, PA 19107 USA

[2] Univ Auckland, Dept Mol Med, Auckland 1, New Zealand

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 12期

关键词：

D O I：

10.1016/S0166-2236(00)01954-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.

引用

收藏

页码：706 / 712

页数：7

相关论文

共 87 条

[1] 3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTS IN HUMAN BRAIN [J].

ADAMS, MD ;

KERLAVAGE, AR ;

FIELDS, C ;

VENTER, JC .

NATURE GENETICS, 1993, 4 (03) :256-267

[2] Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide [J].

Alexeev, V ;

Igoucheva, O ;

Domashenko, A ;

Cotsarelis, G ;

Yoon, K .

NATURE BIOTECHNOLOGY, 2000, 18 (01) :43-47

[3] Convection-enhanced delivery of AAV vector in parkinsonian monkeys;: In vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach [J].

Bankiewicz, KS ;

Eberling, JL ;

Kohutnicka, M ;

Jagust, W ;

Pivirotto, P ;

Bringas, J ;

Cunningham, J ;

Budinger, TF ;

Harvey-White, J .

EXPERIMENTAL NEUROLOGY, 2000, 164 (01) :2-14

[4] Cytokine production in motor neurons by poliovirus replicon vector gene delivery [J].

Bledsoe, AW ;

Jackson, CA ;

McPherson, S ;

Morrow, CD .

NATURE BIOTECHNOLOGY, 2000, 18 (09) :964-969

[5]

Blomer U, 1997, J VIROL, V71, P6641

[6] Adenovirus-mediated transgene expression in nonhuman primate brain [J].

Bohn, MC ;

Choi-Lundberg, DL ;

Davidson, BL ;

Leranth, C ;

Kozlowski, DA ;

Smith, JC ;

O'Banion, MK ;

Redmond, DE .

HUMAN GENE THERAPY, 1999, 10 (07) :1175-1184

[7] ABNORMALLY PHOSPHORYLATED TAU-PROTEIN RELATED TO THE FORMATION OF NEUROFIBRILLARY TANGLES AND NEUROPIL THREADS IN THE CEREBRAL-CORTEX OF SHEEP AND GOAT [J].

BRAAK, H ;

BRAAK, E ;

STROTHJOHANN, M .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :1-4

[8]

BREITLING F, 1999, RECOMBINANT ANTIBODI, P98

[9] Use of the herpes amplicon system as a vehicle for somatic gene transfer [J].

Brooks, AI ;

Halterman, MW ;

Federoff, HJ .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 27 (01) :29-39

[10] Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor [J].

Buxbaum, JD ;

Liu, KN ;

Luo, YX ;

Slack, JL ;

Stocking, KL ;

Peschon, JJ ;

Johnson, RS ;

Castner, BJ ;

Cerretti, DP ;

Black, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :27765-27767

← 1 2 3 4 5 6 7 8 9 →