T2* measurements in human brain at 1.5, 3 and 7 T

被引：187

作者：

Peters, Andrew M.

Brookes, Matthew J.

Hoogenraad, Frank G.

Gowland, Penny A.

Francis, Susan T.

Morris, Peter G.

Bowtell, Richard ^{[1
]}

机构：

[1] Univ Nottingham, Sch Phys & Astron, Sir Peter Mansfield Magnet Resonance Ctr, Nottingham NG7 2RD, England

[2] Philips Med Syst, MR Clin Sci, NL-5680 DA Best, Netherlands

来源：

MAGNETIC RESONANCE IMAGING | 2007年 / 25卷 / 06期

基金：

英国医学研究理事会;

关键词：

T-2*; human brain; mapping; field strength;

D O I：

10.1016/j.mri.2007.02.014

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Measurements have been carried out in six subjects at magnetic fields of 1.5, 3 and 7 T, with the aim of characterizing the variation of T-2* with field strength in human brain. Accurate measurement of T-2* in the presence of macroscopic magnetic field inhomogeneity is problematic due to signal decay resulting from through-slice dephasing. The approach employed here allowed the signal decay due to through-slice dephasing to be characterized and removed from data, thus facilitating an accurate measurement of T-2* even at ultrahigh field. Using double inversion recovery turbo spin-echo images for tissue classification, an analysis of T-2* relaxation times in cortical grey matter and white matter was carried out, along with an evaluation of the variation of T-2* with field strength in the caudate nucleus and putamen. The results show an approximately linear increase in relaxation rate R-2* with field strength for all tissues, leading to a greater range of relaxation times across tissue types at 7 T that can be exploited in high-resolution T-2*-weighted imaging. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：748 / 753

页数：6

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