The two faces of serotonin in bone biology

被引：201

作者：

Ducy, Patricia ^{[1
]}

Karsenty, Gerard ^{[2
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Genet & Dev, New York, NY 10032 USA

来源：

JOURNAL OF CELL BIOLOGY | 2010年 / 191卷 / 01期

基金：

美国国家卫生研究院;

关键词：

TRYPTOPHAN-HYDROXYLASE ISOFORM; RECEPTOR-RELATED PROTEIN-5; PARATHYROID-HORMONE; WEIGHT HOMEOSTASIS; LEPTIN REGULATION; GENETIC-CONTROL; BODY-WEIGHT; LRP5; OSTEOPOROSIS; NEURONS;

D O I：

10.1083/jcb.201006123

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The serotonin molecule has some remarkable properties. It is synthesized by two different genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast, when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis.

引用

页码：7 / 13

页数：7

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