Near infrared Raman spectroscopy to study the composition of human brain tissue and tumors

被引：20

作者：

Krafft, C ^{[1
]}

Miljanic, S ^{[1
]}

Sobottka, SB ^{[1
]}

Schackert, G ^{[1
]}

Salzer, R ^{[1
]}

机构：

[1] Dresden Univ Technol, Inst Analyt Chem, D-01062 Dresden, Germany

来源：

DIAGNOSTIC OPTICAL SPECTROSCOPY IN BIOMEDICINE II | 2003年 / 5141卷

关键词：

Raman spectroscopy; brain tissue; brain tumors; tumor diagnostics;

D O I：

10.1117/12.500469

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The composition of human brain tissue and brain tumors were studied by near infrared Raman spectroscopy with 785 nm excitation. The amounts of lipids, cholesterol, protein and water in fresh specimens were determined from Raman spectra by a combination of pure component spectra. Normal brain tissue was found to contain higher levels of lipids and cholesterol, brain tumors such as glioma and meningeoma displayed less lipids and cholesterol, but more proteins, in particular more hemoglobin-like molecules. These results demonstrate the applicability of Raman spectroscopy for real-time, in vivo, intraoperative diagnosis.

引用

页码：230 / 236

页数：7

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