In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study

被引：82

作者：

Vernet, Celine ^{[1
]}

Pin, Isabelle ^{[1
,2
]}

Giorgis-Allemand, Lise ^{[1
]}

Philippat, Claire ^{[1
]}

Benmerad, Meriem ^{[1
]}

Quentin, Joane ^{[1
,2
]}

Calafat, Antonia M. ^{[3
]}

Ye, Xiaoyun ^{[3
]}

Annesi-Maesano, Isabella ^{[4
,5
]}

Siroux, Valerie ^{[1
]}

Slama, Remy ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CNRS, IAB,U1209,INSERM, Team Environm Epidemiol Appl Reprod & Resp Hlth, Grenoble, France

[2] CHU Grenoble, Serv Pediat, Grenoble, France

[3] Natl Ctr Environm Hlth, Div Lab Sci, Ctr Dis Control & Prevent, Atlanta, GA USA

[4] Sorbonnes Univ, Epidemiol Allerg & Resp Dis EPAR Dept, IPLESP, INSERM, Paris, France

[5] Sorbonnes Univ, UPMC Paris 6, Paris, France

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2017年 / 125卷 / 09期

基金：

欧洲研究理事会;

关键词：

BISPHENOL-A EXPOSURE; PRENATAL EXPOSURE; LUNG-FUNCTION; ASTHMA; AGE; WHEEZE; TRICLOSAN; CHEMICALS; RESPONSES; CHILDREN;

D O I：

10.1289/EHP1015

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Determinants pre du developpement et de la sante de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples. Respiratory outcomes were followed up by questionnaires until age 5, when forced expiratory volume in 1 s (FEV1) was measured by spirometry. Adjusted associations of urinary metabolites log-transformed concentrations with respiratory outcomes and FEV1 in percent predicted (FEV1%) were estimated by survival and linear regression models, respectively. RESULTS: No phenol or phthalate metabolite exhibited clear deleterious associations simultaneously with several respiratory outcomes. Ethyl-paraben was associated with increased asthma rate [hazard rate (HR) = 1.10; 95% confidence interval (CI): 1.00, 1.21] and tended to be negatively associated with FEV1% (beta = -0.59; 95% CI: -1.24, 0.05); bisphenol A tended to be associated with increased rates of asthma diagnosis (HR=1.23; 95% CI: 0.97, 1.55) and bronchiolitis/bronchitis (HR = 1.13; 95% CI: 0.99, 1.30). Isolated trends for deleterious associations were also observed between 2,5-dichlorophenol and wheezing, and between monocarboxynonyl phthalate, a metabolite of di-isodecyl phthalate (DIDP), and wheezing. CONCLUSION: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. https://doi.org/10.1289/EHP1015.

引用

页数：10

共 41 条

[41]

Asthma in Inner-City Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children's Environmental Health Cohort [J].

Whyatt, Robin M. ;

Perzanowski, Matthew S. ;

Just, Allan C. ;

Rundle, Andrew G. ;

Donohue, Kathleen M. ;

Calafat, Antonia M. ;

Hoepner, Lori A. ;

Perera, Frederica P. ;

Miller, Rachel L. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2014, 122 (10) :1141-1146

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