Azobenzene photoswitches for biomolecules

被引：1510

作者：

Beharry, Andrew A. ^{[1
]}

Woolley, G. Andrew ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 08期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

ELECTRONIC-ABSORPTION-SPECTRA; CYCLIC TERMINAL GROUPS; CIS-TRANS ISOMERIZATION; PEPTIDE HELIX CONTENT; DNA-BINDING SPECIFICITY; AZO DYES; ION CHANNELS; CROSS-LINKER; THERMAL CIS; AMINO-ACID;

D O I：

10.1039/c1cs15023e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The photoisomerization of azobenzene has been known for almost 75 years but only recently has this process been widely applied to biological systems. The central challenge of how to productively couple the isomerization process to a large functional change in a biomolecule has been met in a number of instances and it appears that effective photocontrol of a large variety of biomolecules may be possible. This critical review summarizes key properties of azobenzene that enable its use as a photoswitch in biological systems and describes strategies for using azobenzene photoswitches to drive functional changes in peptides, proteins, nucleic acids, lipids, and carbohydrates (192 references).

引用

页码：4422 / 4437

页数：16

共 196 条

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