A highly effective rhodium spirocyclic phosphinite catalyst for the asymmetric hydrogenation of enamides

被引：39

作者：

Hu, WH

Yan, M

Lau, CP

Yang, SM

Chan, ASC ^{[1
]}

Jiang, YZ

Mi, AQ

机构：

[1] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

[3] Acad Sinica, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Chengdu 610015, Peoples R China

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(98)02576-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium complex of the phosphinite ligand spirOP was found to be an effective catalyst for the asymmetric catalytic hydrogenation of alpha-substituted enamides with ee values ranging from 85.1% to 97.4%. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：973 / 976

页数：4

相关论文

共 18 条

[1]

BOSNICH B, 1986, ASYMMETRIC CATALYSIS

[2] A convenient asymmetric synthesis of alpha-1-arylalkylamines through the enantioselective hydrogenation of enamides [J].

Burk, MJ ;

Wang, YM ;

Lee, JR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (21) :5142-5143

[3] Novel spiro phosphinite ligands and their application in homogeneous catalytic hydrogenation reactions [J].

Chan, ASC ;

Hu, WH ;

Pai, CC ;

Lau, CP ;

Jiang, YZ ;

Mi, AQ ;

Yan, M ;

Sun, J ;

Lou, RL ;

Deng, JG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (40) :9570-9571

[4] ENANTIOSELECTIVE SYNTHESIS OF ALPHA-SUBSTITUTED PRIMARY AMINES BY NUCLEOPHILIC-ADDITION TO ALDEHYDE-SAMP HYDRAZONES [J].

ENDERS, D ;

SCHUBERT, H ;

NUBLING, C .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (12) :1109-1110

[5] NEW EFFICIENT METHODS FOR THE SYNTHESIS AND INSITU PREPARATION OF RUTHENIUM(II) COMPLEXES OF ATROPISOMERIC DIPHOSPHINES AND THEIR APPLICATION IN ASYMMETRIC CATALYTIC HYDROGENATIONS [J].

HEISER, B ;

BROGER, EA ;

CRAMERI, Y .

TETRAHEDRON-ASYMMETRY, 1991, 2 (01) :51-62

[6]

JACQUELINE HP, 1995, CHIRAL AUXILIARIES L, P57

[7]

Jacques J., 1981, Enantiomers, Racemates and Resolutions

[8] GENERAL ASYMMETRIC-SYNTHESIS OF BENZOMORPHANS AND MORPHINANS VIA ENANTIOSELECTIVE HYDROGENATION [J].

KITAMURA, M ;

HSIAO, Y ;

NOYORI, R ;

TAKAYA, H .

TETRAHEDRON LETTERS, 1987, 28 (41) :4829-4832

[9] EFFECTS OF THE DIARYLPHOSPHINO GROUPS OF MODIFIED DIOPS ON THE ENANTIOSELECTIVITY AND THE CATALYTIC ACTIVITY OF THEIR RHODIUM(I) COMPLEXES IN THE CATALYTIC ASYMMETRIC HYDROGENATIONS OF ENAMIDES [J].

MORIMOTO, T ;

CHIBA, M ;

ACHIWA, K .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (10) :2894-2896

[10]

Nogradi M., 1995, STEREOSELECTIVE SYNT