Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

被引：51

作者：

Bussy, Cyrill ^{[1
,2
,3
]}

Cambedouzou, Julien ^{[1
]}

Lanone, Sophie ^{[2
,3
]}

Leccia, Emilie ^{[1
]}

Heresanu, Vasile ^{[1
]}

Pinault, Mathieu ^{[4
]}

Mayne-I'Hermite, Martine ^{[4
]}

Brun, Nathalie ^{[1
]}

Mory, Claudie ^{[1
]}

Cotte, Marine ^{[5
]}

Doucet, Jean ^{[1
]}

Boczkowski, Jorge ^{[2
,3
,6
]}

Launoist, Pascale ^{[1
,6
]}

机构：

[1] Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France

[2] Univ Paris 07, INSERM, U700, F-75018 Paris, France

[3] Univ Paris 07, Fac Med Paris 7, F-75018 Paris, France

[4] CEA, DSM IRAMIS SPAM, CNRS, URA 2453,Lab Francis Perrin, F-91191 Gif Sur Yvette, France

[5] European Synchrotron Radiat Facil, F-38043 Grenoble, France

[6] Hop Bichat Claude Bernard, AP HP, CIC 07, F-75018 Paris, France

来源：

NANO LETTERS | 2008年 / 8卷 / 09期

关键词：

D O I：

10.1021/nl800914m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

X-ray fluorescence microscopy (mu XRF) is applied for the first time to study macrophages exposed to unpurified and purified single-walled (SW) and multiwalled (MW) carbon nanotubes (CNT). Investigating chemical elemental distributions allows one to (I) image nanotube localization within a cell and (ii) detect chemical modification of the cell after CNT internalization. An excess of calcium is detected for cells exposed to unpurified SWCNT and MWCNT and related toxicological assays are discussed.

引用

收藏

页码：2659 / 2663

页数：5

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