Synthesis of prolinal dithioacetals as catalysts for the highly stereoselective Michael addition of ketones and aldehydes to β-nitrostyrenes

被引：34

作者：

Mandal, Tanmay ^{[1
]}

Zhao, Cong-Gul ^{[1
]}

机构：

[1] Univ Texas, Dept Chem, San Antonio, TX 78249 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 33期

关键词：

asymmetric; dithioacetals; beta-nitrostyrene; N-Boc-prolinal; proline; enantioselective; diastereoselective;

D O I：

10.1016/j.tetlet.2007.06.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic highly enantioselective (up to > 99% ee) and diastereoselective (up to 99% de) direct Michael addition of ketones and aldehydes to beta-nitrostyrenes have been achieved with readily accessible and highly tunable prolinal dithioacetal catalysts. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：5803 / 5806

页数：4

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