Finding the right spot to start transcription

被引：1

作者：

Cramer, Patrick

机构：

[1] Univ Munich, Dept Chem & Biochem, Gene Ctr Munich, D-81377 Munich, Germany

[2] Univ Munich, Dept Chem & Biochem, Ctr Integrated Prot Sci, D-81377 Munich, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 08期

关键词：

D O I：

10.1038/nsmb0807-686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How does RNA polymerase II cooperate with initiation factors to locate transcription start sites throughout the genome? A new cross-linking approach reveals previously unknown initiation factor–binding sites on the polymerase surface. The resulting model of the transcription initiation complex suggests that initiation factors cooperate above and inside the polymerase active center cleft to open DNA and find the transcription start site.

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页码：686 / 687

页数：3

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