Axonal ephrin-as and odorant receptors:: Coordinate determination of the olfactory sensory map

被引:177
作者
Cutforth, T
Moring, L
Mendelsohn, M
Nemes, A
Shah, NM
Kim, MM
Frisén, J
Axel, R [1 ]
机构
[1] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
[2] Columbia Univ, Ctr Neurobiol & Behav, Coll Phys & Surg, New York, NY 10032 USA
[3] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
关键词
D O I
10.1016/S0092-8674(03)00568-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Olfactory sensory neurons expressing a given odorant receptor (OR) project with precision to specific glomeruli in the olfactory bulb, generating a topographic map. In this study, we demonstrate that neurons expressing different ORs express different levels of ephrin-A protein on their axons. Moreover, alterations in the level of ephrin-A alter the glomerular map. Deletion of the ephrin-A5 and ephrin-A3 genes posteriorizes the glomerular locations for neurons expressing either the P2 or SR1 receptor, whereas overexpression of ephrin-A5 in P2 neurons results in an anterior shift in their glomeruli. Thus the ephrin-As are differentially expressed in distinct subpopulations of neurons and are likely to participate, along with the ORs, as one of a complement of guidance receptors governing the targeting of like axons to precise locations in the olfactory bulb.
引用
收藏
页码:311 / 322
页数:12
相关论文
共 57 条
[21]   Mechanisms and functions of EPH and ephrin signalling [J].
Kullander, K ;
Klein, R .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (07) :475-486
[22]   Genomic analysis of orthologous mouse and human olfactory receptor loci [J].
Lane, RP ;
Cutforth, T ;
Young, J ;
Athanasiou, M ;
Friedman, C ;
Rowen, L ;
Evans, G ;
Axel, R ;
Hood, L ;
Task, BJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7390-7395
[23]   Topographic mapping in dorsoventral axis of the xenopus retinotectal system depends on signaling through ephrin-13 ligands [J].
Mann, F ;
Ray, S ;
Harris, WA ;
Holt, CE .
NEURON, 2002, 35 (03) :461-473
[24]   Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping [J].
McLaughlin, T ;
Hindges, R ;
Yates, PA ;
O'Leary, DM .
DEVELOPMENT, 2003, 130 (11) :2407-2418
[25]   Visualizing an olfactory sensory map [J].
Mombaerts, P ;
Wang, F ;
Dulac, C ;
Chao, SK ;
Nemes, A ;
Mendelsohn, M ;
Edmondson, J ;
Axel, R .
CELL, 1996, 87 (04) :675-686
[26]   How smell develops [J].
Mombaerts, P .
NATURE NEUROSCIENCE, 2001, 4 (Suppl 11) :1192-1198
[27]   Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1 [J].
Montag-Sallaz, M ;
Schachner, M ;
Montag, D .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (22) :7967-7981
[28]   Molecular development of sensory maps: Representing sights and smells in the brain [J].
O'Leary, DDM ;
Yates, PA ;
McLaughlin, T .
CELL, 1999, 96 (02) :255-269
[29]   Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging [J].
Prakash, N ;
Vanderhaeghen, P ;
Cohen-Cory, S ;
Frisén, J ;
Flanagan, JG ;
Frostig, RD .
JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5841-5847
[30]   Role of galectin-1 in the developing mouse olfactory system [J].
Puche, AC ;
Poirier, F ;
Hair, M ;
Bartlett, PF ;
Key, B .
DEVELOPMENTAL BIOLOGY, 1996, 179 (01) :274-287