The Vilsmeier reagent as an efficient acid activator for the synthesis of β-lactams

被引：51

作者：

Jarrahpour, Aliasghar ^{[1
]}

Zarei, Maaroof ^{[1
]}

机构：

[1] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 71454, Iran

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 49期

关键词：

Vilsmeier reagent; beta-lactam; Staudinger reaction; acid activator; cycloaddition reaction;

D O I：

10.1016/j.tetlet.2007.10.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Vilsmeier reagent (chloromethylenedimethylammonium chloride) has been used as an efficient and cheap acid activator for the one-step Staudinger reaction of substituted acetic acids and imines under mild conditions. This reaction is clean and the by-products are DMF and triethylamine hydrochloride which were removed by simple aqueous work-up. (c) 2007 Published by Elsevier Ltd.

引用

页码：8712 / 8714

页数：3

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